Long COVID risk no lower with breakthrough infection; COVID-19 survival improves for European cancer patients By Reuters

© Reuters. A person receives his third dose of coronavirus illness (COVID-19) vaccine at a Red Cross vaccination centre by Termini, Rome’s most important practice station, as the federal government discusses extra stringent guidelines for the well being move generally known as a Green Pass, in Rome, Italy Nov

By Nancy Lapid

(Reuters) – The following is a abstract of some latest research on COVID-19. They embody analysis that warrants additional examine to corroborate the findings and that has but to be licensed by peer evaluate.

Long COVID risk not lower after breakthrough an infection

COVID-19 vaccines are extremely efficient in defending in opposition to severe sickness, however they don’t defend in opposition to “long COVID” in individuals who grow to be contaminated regardless of vaccination, new information present. For six months, researchers tracked 9,479 vaccinated people identified with COVID-19 and about the identical variety of contaminated patients who had not been vaccinated. Compared to the unvaccinated patients, individuals with so-called breakthrough infections had been “at a much lower risk of severe complications of COVID-19” such because the have to be admitted to an intensive care unit, requiring respiratory help, or growing a blood clot of their legs or lungs, stated Maxime Taquet of the University of Oxford. But different problems of the virus, together with the syndrome of lingering signs generally known as lengthy COVID, occurred at related charges no matter vaccination standing, his workforce stated in a paper posted on medRxiv forward of peer evaluate. In individuals over age 60 with breakthrough infections, vaccines protected in opposition to COVID-19 problems solely weakly or in no way, Taquet famous. “Vaccines are still an excellent way to prevent any complication of COVID-19 (including long COVID) since they prevent infection in the first place,” Taquet stated. “However, these findings show that those who get infected despite being vaccinated should remain vigilant about potential complications of their illness.”

COVID-19 survival has improved for European cancer patients

European cancer patients who get sick with COVID-19 are more likely to outlive now than they had been earlier within the pandemic, researchers discovered. They reviewed the outcomes of greater than 2,600 cancer patients with coronavirus infections handled in six international locations between February 2020 and February 2021 to calculate demise charges throughout the first two weeks after analysis. “The initial studies on the topic documented a mortality rate ranging from 30% to 40%… in patients with cancer,” stated Dr. David James Pinato of Imperial College London. “Our study suggests that over the course of the pandemic the mortality has gradually reduced, even before vaccines were implemented, reducing to a figure that was as low as 12.5% during the so called ‘second wave’ in Europe.” Cancer patients identified earlier within the pandemic additionally had extra COVID-19 problems, his workforce reported on Wednesday in JAMA Oncology. The researchers imagine the improved survival is said not solely to raised remedies but in addition to raised availability of COVID-19 assessments that permit for earlier analysis. These components “have been key in improving overall outcome,” Pinato stated.

‘Glimpse of hope’ when medicine restrict vaccine antibodies

People taking a category of medication identified to restrict the antibody response of the mRNA COVID-19 vaccines from Pfizer/BioNTech or Moderna (NASDAQ:) could get some safety from one other a part of the immune system, in keeping with a small examine printed in Clinical Infectious Diseases. The class of anti-CD20 medicine used to deal with rheumatoid arthritis, some cancers and different circumstances, akin to Roche’s Rituxan (rituximab), suppress the immune system. But the brand new findings supply “a glimpse of hope” that these patients could get some safety from the mRNA vaccines in any case, the examine’s chief stated. The researchers studied mRNA vaccine responses in 37 patients taking these medicine for rheumatic illnesses or a number of sclerosis, evaluating them to 22 people with wholesome immune methods. Only about 70% of the patients developed antibodies in response to the mRNA vaccines, and their ranges had been considerably lower than ranges within the wholesome volunteers. However, each teams had equal ranges of immune cells known as T cells that might acknowledge and assault the coronavirus. “Our study suggests that patients on anti-CD20 treatment are able to mount potent T-cell responses to mRNA COVID-19 vaccines,” regardless of impaired antibody responses, the researchers wrote. The measurement of the examine “does not allow us to draw firm conclusions about protection from severe COVID-19 in these patients,” stated Dr. Christiane Eberhardt of the University of Geneva in Switzerland. They “should still be vigilant and protect themselves from getting infected.”

Graphic: Vaccines in growth:

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